BIO 3520
McGilliard
 
 

Reading Assignment:

    Widmaier, pp. 137-143, 146-171.
 

Objectives:

     After reviewing your lecture notes and reading assignment, you should be able to:

     1.  Describe the structure of a typical neuron.

          Lecture -- 9/05
          Text -- pp. 137-139
          Figure -- 6-1
          Structure of the Neuron

     2.  Define the resting membrane potential, give an approximate value in the nerve cell,

          and explain how this potential is maintained.

          Lecture -- 9/05
          Text -- pp. 144-146
          Figure -- 6-8
          Table -- 6-3
          Film:  The Nerve Impulse
          Notes
          Recording from an Axon

     3.  Use the Goldman equation to predict the membrane potential under various
          conditions.

          Lecture -- 9/05
          Text -- pp. 147-148

          Notes

     4.  Define:

          a.  Depolarization.

          b.  Repolarization.

          c.  Hyperpolarization.

          Lecture -- 9/07

          Text -- pp. 149-150

          Figure -- 6-14

          Notes

     5.  Contrast the properties of a graded potential with those of an action potential.

          Lecture -- 9/07, 9/12
          Text -- pp. 149-154
          Figure -- 6-16
          Table -- 6-4
          Notes

     6.  Explain the ionic hypothesis of the action potential.

          Lecture -- 9/10, 9/12
          Text -- pp. 153-154
          Figures -- 6-18, 6-19, 6-20

          Film:  The Nerve Impulse
          Voltage Clamp Experiments

     7.  Identify the actions of drugs that alter ion channels and their subsequent effects
          on nerve function.

          Lecture -- 9/12
          Text -- pp. 154

     8.  Define absolute refractory period and relative refractory period and explain their

          importance in nerve impulse conduction.

          Lecture -- 9/12
          Text -- pg. 154-155
          Refractory Periods
          Notes

     9.  Describe the propagation of an action potential and the role of myelin in nerve

          impulse conduction.

          Lecture -- 9/12
          Text -- pp. 138-139, 155-157
          Figures -- 6-2, 6-22, 6-23
          Notes
          Propagation of an Action Potential
          Myelin Sheath
          Myelin Sheath and Impulse Conduction

   10.  Describe the synapse and discuss the process of synaptic transmission.

          Lecture -- 9/14
          Text -- pp. 159-161
          Figures -- 6-25, 6-27
          Synapse
          Synaptic Transmission
          Structure of Neuron and Synapse (Quiz Yourself)

   11.  Contrast excitatory and inhibitory postsynaptic potentials.

          Lecture -- 9/14
          Text -- pp. 161-164
          Figures -- 6-28, 6-29, 6-31
          Integration of Postsynaptic Potentials

   12.  Name five neurotransmitters and give examples of drugs or diseases that alter

          neurotransmitter actions.

          Lecture -- 9/14
          Text -- pp. 165-171
          Notes

   13.  Describe three ways in which neurotransmitter action is terminated.

          [Not covered]

          Text -- pp. 166-167
          Action of Acetylcholinesterase

   14.  Identify a significant contribution of each of the following scientists to the field

          of neurophysiology:
          a.  Luigi Galvani.  Lecture -- 1/24
          b.  Camillo Golgi.  Lecture -- 1/24
          c.  Santiago Ramon y Cajal.  Lecture -- 1/24
          d.  Alan Hodgkin.  Lecture -- 9/10
          e.  Andrew Huxley.  Lecture -- 9/10
          f.  Otto Loewi.  Lecture -- 9/14

          Film:  The Nerve Impulse
          Notes
          The Discovery of Chemical Neurotransmission
 

Review Questions:

     Pg. 143, #1.
     Pg. 159, #4-6, 8-12.
     Pg. 173, #1.
 

Test Questions:

     Pp. 189, #7, 8.

Quantitative and Thought Questions:

     Pg. 190, #2, 7.