McGilliard
PHYSIOLOGY OF THE CELL MEMBRANE
Preparation:
A general knowledge of organic chemistry is
necessary to understand many of the processes taking place in the cell.
Before beginning this unit, you should familiarize yourself with the following
terms, which can be found in Chapter 2 of Widmaier:
|
Amino acid Hydroxyl group Lipid Monosaccharide Nonpolar |
Nucleic acid
Protein Triglyceride |
You should also be familiar with the structural
organization of the cell, which is discussed in Widmaier, pp. 43-54 and fig.
3-4.
Reading Assignment:
Widmaier, pp. 24-26, 45-49, 66-69, 96-116, 120-131, 144-148.
Objectives:
After reviewing your lecture notes and reading assignment, you should be able to:
1. Discuss four properties of water that are important in physiology.
Lecture -- 8/29
Text -- pg. 24
Figures --
2-4,
2-5
Notes
2. Describe the fluid-mosaic model of the cell membrane.
Lecture -- 8/29, 9/03
Text -- pp. 45-48
3. Name and give examples of four characteristics of protein binding sites.
Lecture -- 8/29
Text
-- pp. 66-69
Figures --
3-26,
3-27,
3-28,
3-29,
3-30,
3-31
Notes
4. Describe the structures and functions of desmosomes, tight junctions, and gap junctions.
Lecture -- 8/29
Text -- pp. 48-49
Figure -- 3-10
5. State the Second Law of Thermodynamics and discuss how this law may be applied
to the movement of molecules.
Lecture -- 8/29
6. Define:
a. Diffusion. Text -- pg. 97; Figures -- 4-1, 4-2
b. Osmosis. Text -- pg. 108; Figure -- 4-18
c. Osmolarity. Text -- pg. 109
d. Osmotic pressure. Text -- pg. 110
e. Isoosmotic. Text -- pg. 111
f. Isotonic. Text -- pg. 111
g. Hypotonic. Text -- pg. 111
h. Hypertonic. Text -- pg. 111
Lecture/Lab -- 8/29, 9/02, 9/03
Table -- 4-3
7. Using Fick's law, discuss the factors that are important in determining the rate of
diffusion of a substance across a membrane.
Lecture/Lab -- 8/29, 9/02, 9/03
Text -- pp. 97-99
Figure -- 4-3
Relationship between Lipid Solubility and Membrane Permeability
8. Describe the mechanism responsible for the swelling of a red blood cell in the
presence of a hypotonic solution.
Lab -- 9/02, 9/03
Text -- 110-112
Figure -- 4-19
Red Blood Cells in Isotonic, Hypotonic, and Hypertonic Solutions
9. Discuss three factors that govern the diffusion of ions across the cell membrane.
Lecture -- 8/29, 9/03
Text -- pp. 97-100
Figure -- 4-7
10. Describe the relative distribution of sodium, potassium, and chloride ions inside and
outside of the cell.
Lecture -- 9/03
Text -- pg. 145
Table -- 6-2
11. Define and explain the membrane potential.
Lecture -- 9/03
Text -- pp. 100, 144-146
12. Use the Nernst equation to calculate the equilibrium potential for a specific ion.
Lecture -- 9/03
Text -- pp. 146-147
13. Differentiate between diffusion, facilitated diffusion,
primary active transport, and
secondary active
transport.
Lecture -- 9/05
Text -- pp. 97-99, 102-108
Figures -- 4-7, 4-8, 4-10, 4-11, 4-12, 4-13
Table -- 4-2
14. Describe the processes of endocytosis and exocytosis and give an example of each.
Lecture -- 9/05
Text -- pp. 112-114
Figure -- 4-20
15. Describe the mechanisms responsible for the transport of glucose across the intestinal
epithelial cell.
Lecture -- 9/08
Text -- pp. 114-116
16. Discuss two mechanisms by which ligands produce their effects when binding to
membrane receptors.
Lecture -- 9/08
Text -- pp. 121-126
Figures -- 5-5a,
5-5d
17. Define and give two examples of second messengers.
Lecture -- 9/08
Text -- pp. 124-131
Figures -- 5-6, 5-7, 5-8, 5-11
18. Explain the principles behind the operation of the spectrophotometer.
Lab -- 9/02, 9/03
Review Questions:
Pg. 41, #9-11.
Pg. 55, #3-6.
Pg. 71, #1-3, 5, 6.
Pg. 117, #1-9, 12, 14, 15, 17.
Pg. 135, #1, 4, 7, 10.
Pg. 159, #1, 3.
Test Questions:
Pg. 118, #1, 2, 5, 6.
Pg. 136, #1-3.
Pg. 189, #3.
Quantitative and Thought Questions:
Pg. 95, #6.
Pg. 118, #1-4, 6.
Pg. 136, #5.
[Note: Answers to Test Questions and Quantitative and Thought Questions are found in Appendix A.]
Updated 8/27/08
