BIO 5406
McGilliard

Reading Assignment:

     Hadley, pp. 254, 315-334, 338-339.

     Carmichael, S.W. and Winkler, H.  The adrenal chromaffin cell.  Sci. Amer. 253(2): 40-49,
          August 1985.

     Lagercrantz, H. and Slotkin, T.A.  The "stress" of being born.  Sci. Amer. 254(4): 100-107,
          April 1986.

Objectives:

     After reviewing your lecture notes and reading assignment, you should be able to:

     1.  Describe the histological features of the adrenal medulla.

          Lecture -- 2/11
          Text -- pp. 317-319
          Figure -- 15.2
          Carmichael and Winkler
          Anatomy of the adrenal gland
          Section of adrenal gland (low power)

     2.  Outline the biosynthesis of epinephrine from tyrosine, including the names and

          locations of the enzymes involved.

          Lecture -- 2/11
          Text -- pp. 320-321
          Figure -- 14.3
          Catecholamine biosynthetic pathway
          Carmichael and Winkler

     3.  Name four stimuli to secretion of epinephrine.

          Lecture -- 2/11
          Text -- pp. 254, 321, 332

     4.  Describe the biological actions of epinephrine.

          Lecture -- 2/11
          Text -- pp. 329-332
          Lagercrantz and Slotkin

     5.  Describe the mechanism of action of epinephrine, using its effect on hepatic

          glycogen as an example.

          Lecture -- 2/13

          Text -- 323-328
          Figures -- 14.6, 14.9, 14.10, 14.11
          Structure of the beta-adrenergic receptor
          Cyclic AMP second messenger system

     6.  Discuss the possible physiological roles of stress and catecholamine release

          during parturition.

          Lecture -- 2/13

          Lagercrantz and Slotkin

     7.  Outline the probable physiological roles of catecholamines and the relative

          predominance of epinephrine vs. norepinephrine secretion in various vertebrate

          species.

          Lecture -- 2/13

          Text -- pp. 319, 333-334

     8.  Describe the contributions of the following scientists to the field of endocrinology:
          a.  Walter Cannon.
          b.  Raymond Ahlquist.
          c.  James Black.

          Text -- pp. 4, 315-316, 323
          1988 Nobel Press Release