catalog's:
Basic
principles of
pharmacology, drug-receptor interaction, physicochemical properties as
related to biological activity; synthesis of medicinally important
molecules including strategic considerations. Prerequisites: CHM
2440/2430 and permission of instructor or CHM 2840.
mine:
The course is roughly divided into three sections. The first portion
will primarily cover pharmacology, with special focus on the
shape/electron distribution of molecules and how these affect their
travels throughout the body, including receptor & protein binding,
metabolism/excretion, toxicity, and tolerance/dependence/ addiction.
In the second part,
we'll cover a series of drug families, most of which you'll choose;
we'll discuss the lead compound(s), development (including SAR
studies), synthesis (including industrial), and pharmacokinetics/
pharmacodynamics. The third section will deal with drug
development, with particular focus on QSAR and computer modeling
techniques, including pharmacophore identification and drug-receptor
docking.
